CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C01787
Pert ID:	BRD-K54759182
Compound Name:	dosulepin
Targets:	CHRM1\|CHRM2\|CHRM3\|CHRM4\|CHRM5\|HRH1\|SLC6A2\|SLC6A4
MoA:	norepinephrine reuptake inhibitor; serotonin norepinephrine reuptake inhibitor (SNRI); tricyclic antidepressant
SMILES:	CN(C)CC\C=C1/c2ccccc2CSc2ccccc12
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
3236	BRD-K54759182	HCC515	10 uM	24 h	0.27	1.15	0.32	0.0	0.0	0.0
3835	BRD-K54759182	VCAP	10 uM	24 h	0.0	0.0	0.0	0.23	0.82	0.1
41951	BRD-K54759182	A549	10 uM	24 h	0.0	0.0	0.0	-0.2	-0.67	0.01
42398	BRD-K54759182	ASC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
42717	BRD-K54759182	HEPG2	10 uM	6 h	-0.26	-1.1	0.34	0.0	0.0	0.0
43583	BRD-K54759182	NPC	10 uM	24 h	0.0	0.0	0.0	-0.35	-1.18	1.15
43886	BRD-K54759182	PHH	10 uM	24 h	-0.21	-0.86	0.02	-0.26	-0.89	0.26
44143	BRD-K54759182	SKB	10 uM	24 h	-0.18	-0.76	0.0	0.0	0.0	0.0
99662	BRD-K54759182	U2OS	6.66 uM	6 h	-0.19	-0.79	0.0	0.0	0.0	0.0
121612	BRD-K54759182	HA1E	0.125 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
121688	BRD-K54759182	MCF??7.00	0.37 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
129585	BRD-K54759182	A375	0.74 uM	24 h	0.25	1.05	0.17	-0.32	-1.07	0.76
129610	BRD-K54759182	HELA	0.01 uM	24 h	0.0	0.0	0.0	-0.19	-0.63	0.0
129643	BRD-K54759182	HT29	0.01 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
129701	BRD-K54759182	PC3	0.01 uM	24 h	-0.26	-1.08	0.3	0.0	0.0	0.0
129734	BRD-K54759182	YAPC	0.03 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary