CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C01789
Pert ID:	BRD-A46179541
Compound Name:	doxapram
Targets:	KCNK3\|KCNK9
MoA:	potassium channel blocker
SMILES:	CCN1CC(CCN2CCOCC2)C(C1=O)(c1ccccc1)c1ccccc1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
22098	BRD-A46179541	A549	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
22646	BRD-A46179541	HCC515	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
22927	BRD-A46179541	HEPG2	10 uM	6 h	0.0	0.0	0.0	-0.22	-0.74	0.06
23512	BRD-A46179541	MCF??7.00	10 uM	24 h	0.21	0.87	0.01	0.0	0.0	0.0
24263	BRD-A46179541	VCAP	10 uM	6 h	0.27	1.13	0.29	-0.34	-1.15	1.07
125236	BRD-A46179541	A375	0.04 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125305	BRD-A46179541	HEK293	0.04 uM	24 h	0.25	1.02	0.13	0.15	0.52	0.0
125492	BRD-A46179541	PC3	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133385	BRD-A46179541	HA1E	0.03 uM	24 h	-0.26	-1.07	0.27	0.0	0.0	0.0
133415	BRD-A46179541	HELA	0.74 uM	24 h	-0.2	-0.82	0.0	0.0	0.0	0.0
133450	BRD-A46179541	HT29	0.01 uM	24 h	0.22	0.9	0.02	0.28	1.0	0.42
133479	BRD-A46179541	JURKAT	0.74 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133511	BRD-A46179541	MCF10A	0.03 uM	24 h	0.2	0.83	0.0	0.26	0.93	0.27
133548	BRD-A46179541	MDAMB231	0.08 uM	24 h	0.24	1.01	0.12	0.0	0.0	0.0
133603	BRD-A46179541	THP1	0.25 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133626	BRD-A46179541	YAPC	0.01 uM	24 h	0.0	0.0	0.0	0.26	0.93	0.27

Summary