CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C01790
Pert ID:	BRD-A13188892
Compound Name:	doxazosin
Targets:	ADRA1A\|ADRA1B\|ADRA1D\|KCNH2\|KCNH6\|KCNH7
MoA:	adrenergic receptor antagonist
SMILES:	COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2ccccc2O1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
50974	BRD-A13188892	VCAP	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
52232	BRD-A13188892	PC3	10 uM	24 h	0.0	0.0	0.0	-0.28	-0.93	0.34
91246	BRD-A13188892	HUH7	8 uM	72 h	0.0	0.0	0.0	0.0	0.0	0.0
122251	BRD-A13188892	A375	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
122361	BRD-A13188892	MCF10A	10 uM	24 h	0.24	1.0	0.11	0.0	0.0	0.0
122474	BRD-A13188892	THP1	10 uM	24 h	0.36	1.52	1.44	0.0	0.0	0.0
130554	BRD-A13188892	A549	0.03 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
130589	BRD-A13188892	HA1E	0.03 uM	24 h	0.0	0.0	0.0	-0.26	-0.88	0.25
130625	BRD-A13188892	HEK293	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
130666	BRD-A13188892	HELA	0.25 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
130706	BRD-A13188892	HT29	0.74 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
130761	BRD-A13188892	MCF??7.00	0.25 uM	24 h	-0.24	-1.0	0.15	-0.25	-0.83	0.17
130782	BRD-A13188892	MDAMB231	2.22 uM	24 h	0.38	1.58	1.51	0.31	1.11	0.73
130835	BRD-A13188892	YAPC	0.01 uM	24 h	0.0	0.0	0.0	0.3	1.08	0.65

Summary