CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C01794
Pert ID:	BRD-K70507123
Compound Name:	doxofylline
Targets:	ADORA1\|PDE4A\|PDE4B\|PDE4C\|PDE4D
MoA:	adenosine receptor antagonist
SMILES:	Cn1c2ncn(CC3OCCO3)c2c(=O)n(C)c1=O
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
91267	BRD-K70507123	HUH7	12.5 uM	72 h	0.0	0.0	0.0	0.0	0.0	0.0
126695	BRD-K70507123	HEK293	0.125 uM	24 h	0.0	0.0	0.0	-0.28	-0.95	0.4
126720	BRD-K70507123	HELA	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
126782	BRD-K70507123	JURKAT	3.33 uM	24 h	0.0	0.0	0.0	-0.36	-1.2	1.2
126805	BRD-K70507123	MCF10A	0.37 uM	24 h	0.0	0.0	0.0	0.28	1.0	0.42
126843	BRD-K70507123	MCF??7.00	1.11 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
126888	BRD-K70507123	MDAMB231	3.33 uM	24 h	0.0	0.0	0.0	-0.26	-0.88	0.26
126955	BRD-K70507123	THP1	0.125 uM	24 h	0.0	0.0	0.0	-0.3	-1.01	0.58
126997	BRD-K70507123	YAPC	0.04 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
134680	BRD-K70507123	A375	0.03 uM	24 h	0.0	0.0	0.0	-0.34	-1.13	1.0
134702	BRD-K70507123	A549	0.01 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
134730	BRD-K70507123	HA1E	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
134827	BRD-K70507123	HT29	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
134869	BRD-K70507123	HUVEC	0.25 uM	24 h	0.26	1.07	0.2	0.35	1.24	1.28
134966	BRD-K70507123	PC3	0.01 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary