CMap Candidate Details
Structure:
| CMap ID: | C01811 |
| Pert ID: | BRD-K05524748 |
| Compound Name: | dronedarone |
| Targets: | ADRA1A|ADRA1B|ADRA1D|ADRA2A|ADRA2B|ADRA2C|ADRB1|CACNA1C|CACNA1D|CACNA1F|CACNA1S|CACNB1|CACNB2|CACNB3|CACNB4|KCNA5|KCNH2|KCNK2|SCN1A |
| MoA: | adrenergic receptor antagonist |
| SMILES: | CCCCN(CCCC)CCCOc1ccc(cc1)C(=O)c1c(CCCC)oc2ccc(NS(C)(=O)=O)cc12 |
| InchiKey: | |
| Compound Aliases: |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 122538 | BRD-K05524748 | A375 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 122572 | BRD-K05524748 | A549 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.29 | 1.03 | 0.51 |
| 122595 | BRD-K05524748 | HA1E | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 122655 | BRD-K05524748 | HELA | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 122675 | BRD-K05524748 | HT29 | 10 uM | 24 h | 0.2 | 0.84 | 0.0 | 0.0 | 0.0 | 0.0 |
| 122710 | BRD-K05524748 | MCF10A | 10 uM | 24 h | -0.19 | -0.81 | 0.0 | 0.0 | 0.0 | 0.0 |
| 122747 | BRD-K05524748 | MCF??7.00 | 10 uM | 24 h | 0.22 | 0.93 | 0.05 | 0.0 | 0.0 | 0.0 |
| 122766 | BRD-K05524748 | MDAMB231 | 10 uM | 24 h | 0.27 | 1.11 | 0.25 | 0.0 | 0.0 | 0.0 |
| 122788 | BRD-K05524748 | PC3 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 122810 | BRD-K05524748 | YAPC | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 130930 | BRD-K05524748 | HEK293 | 2.22 uM | 24 h | -0.22 | -0.9 | 0.04 | -0.34 | -1.15 | 1.05 |
| 131032 | BRD-K05524748 | HUVEC | 0.01 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.31 | 1.11 | 0.71 |