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CMap Candidate Details

Structure:
CMap ID: C01822
Pert ID: BRD-K71103788
Compound Name: duloxetine
Targets: HTR2A|HTR2C|HTR6|SLC6A2|SLC6A3|SLC6A4
MoA: norepinephrine reuptake inhibitor; serotonin norepinephrine reuptake inhibitor (SNRI)
SMILES: CNCC[C@H](Oc1cccc2ccccc12)c1cccs1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1425 BRD-K71103788 NPC 12.5 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
5680 BRD-K71103788 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
5951 BRD-K71103788 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
24604 BRD-K71103788 A549 10 uM 24 h 0.24 1.0 0.11 0.0 0.0 0.0
25184 BRD-K71103788 PC3 10 uM 24 h 0.0 0.0 0.0 -0.37 -1.23 1.25
25412 BRD-K71103788 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37727 BRD-K71103788 ASC 10 uM 24 h -0.19 -0.8 0.0 -0.23 -0.79 0.1
38770 BRD-K71103788 PHH 10 uM 24 h 0.28 1.17 0.36 -0.22 -0.75 0.06
38998 BRD-K71103788 SKB 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.07 0.77
126634 BRD-K71103788 A375 10 uM 24 h 0.0 0.0 0.0 -0.27 -0.9 0.29
126747 BRD-K71103788 HT29 10 uM 24 h 0.0 0.0 0.0 0.22 0.77 0.06
126786 BRD-K71103788 JURKAT 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126809 BRD-K71103788 MCF10A 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126850 BRD-K71103788 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.39 -1.31 1.69
126894 BRD-K71103788 MDAMB231 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126962 BRD-K71103788 THP1 0.04 uM 24 h -0.32 -1.34 0.98 0.23 0.83 0.11
127000 BRD-K71103788 YAPC 10 uM 24 h 0.0 0.0 0.0 0.38 1.36 1.72
134736 BRD-K71103788 HA1E 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134771 BRD-K71103788 HEK293 0.01 uM 24 h 0.0 0.0 0.0 -0.34 -1.16 1.11
134800 BRD-K71103788 HELA 0.08 uM 24 h 0.29 1.22 0.48 -0.31 -1.05 0.72
134876 BRD-K71103788 HUVEC 2.22 uM 24 h -0.29 -1.19 0.55 -0.27 -0.92 0.31
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).