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CMap Candidate Details

Structure:
CMap ID: C01895
Pert ID: BRD-A65248799
Compound Name: EMD-53998
Targets: TNNC1
MoA: phosphodiesterase inhibitor
SMILES: COc1ccc(cc1OC)C(=O)N1CCCc2cc(ccc12)C1=NNC(=O)SC1C
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
96853 BRD-A65248799 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124975 BRD-A65248799 A549 0.04 uM 24 h -0.24 -1.0 0.15 0.0 0.0 0.0
125118 BRD-A65248799 MDAMB231 3.33 uM 24 h 0.22 0.9 0.02 0.29 1.02 0.48
125177 BRD-A65248799 THP1 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.96 0.44
133018 BRD-A65248799 HA1E 0.03 uM 24 h 0.0 0.0 0.0 0.34 1.22 1.15
133065 BRD-A65248799 HEK293 0.03 uM 24 h 0.0 0.0 0.0 -0.29 -0.98 0.47
133096 BRD-A65248799 HELA 0.01 uM 24 h -0.24 -1.01 0.16 -0.33 -1.13 0.97
133126 BRD-A65248799 HT29 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133172 BRD-A65248799 JURKAT 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133206 BRD-A65248799 MCF10A 0.01 uM 24 h -0.22 -0.93 0.07 0.0 0.0 0.0
133235 BRD-A65248799 MCF??7.00 0.08 uM 24 h 0.28 1.16 0.36 0.27 0.96 0.33
133297 BRD-A65248799 PC3 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133321 BRD-A65248799 YAPC 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).