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CMap Candidate Details

Structure:
CMap ID: C01927
Pert ID: BRD-K79404599
Compound Name: enzastaurin
Targets: AKT1|GSK3B|PRKCA|PRKCB|PRKCD|PRKCG
MoA: PKC inhibitor
SMILES: Cn1cc(C2=C(C(=O)NC2=O)c2cn(C3CCN(Cc4ccccn4)CC3)c3ccccc23)c2ccccc12
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
499 BRD-K79404599 BJAB 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
540 BRD-K79404599 HBL1 10 uM 24 h 0.24 1.02 0.13 0.0 0.0 0.0
579 BRD-K79404599 K562 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
642 BRD-K79404599 KMS34 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
688 BRD-K79404599 MINO 10 uM 24 h 0.0 0.0 0.0 0.22 0.77 0.06
735 BRD-K79404599 NALM6 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
790 BRD-K79404599 OCILY19 0.01 uM 4 h 0.0 0.0 0.0 0.0 0.0 0.0
834 BRD-K79404599 OCILY3 0.125 uM 4 h 0.0 0.0 0.0 -0.25 -0.84 0.18
878 BRD-K79404599 SKMEL5 10 uM 24 h 0.0 0.0 0.0 -0.25 -0.83 0.17
918 BRD-K79404599 THP1 10 uM 24 h 0.28 1.19 0.41 0.28 1.0 0.42
942 BRD-K79404599 TMD8 10 uM 24 h 0.25 1.06 0.18 0.0 0.0 0.0
34181 BRD-K79404599 ASC 10 uM 24 h 0.0 0.0 0.0 0.24 0.85 0.14
34964 BRD-K79404599 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.36 1.27 1.34
35621 BRD-K79404599 NEU 10 uM 24 h -0.23 -0.97 0.11 0.0 0.0 0.0
35843 BRD-K79404599 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36650 BRD-K79404599 SKB 10 uM 24 h 0.3 1.23 0.5 0.37 1.32 1.71
36873 BRD-K79404599 VCAP 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.98 0.48
91665 BRD-K79404599 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.17 0.6 0.0
91697 BRD-K79404599 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91984 BRD-K79404599 A375 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92011 BRD-K79404599 BT20 10 uM 24 h 0.23 0.94 0.06 0.0 0.0 0.0
92057 BRD-K79404599 HA1E 10 uM 24 h 0.19 0.8 0.0 -0.28 -0.94 0.37
92088 BRD-K79404599 HCC515 10 uM 24 h 0.0 0.0 0.0 -0.5 -1.69 15.65
92127 BRD-K79404599 HS578T 10 uM 24 h -0.19 -0.8 0.0 0.0 0.0 0.0
92209 BRD-K79404599 MCF10A 10 uM 24 h 0.32 1.33 0.85 0.0 0.0 0.0
92329 BRD-K79404599 PC3 10 uM 24 h 0.32 1.32 0.82 0.35 1.23 1.24
92358 BRD-K79404599 SKBR3 10 uM 24 h 0.27 1.14 0.32 0.31 1.08 0.67
96028 BRD-K79404599 PHH 3.33 uM 24 h 0.0 0.0 0.0 0.2 0.71 0.02
97295 BRD-K79404599 HAP1 0.66 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127081 BRD-K79404599 HEK293 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127172 BRD-K79404599 JURKAT 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127332 BRD-K79404599 YAPC 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135066 BRD-K79404599 A549 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135136 BRD-K79404599 HELA 0.25 uM 24 h 0.0 0.0 0.0 0.37 1.32 1.6
135154 BRD-K79404599 HT29 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).