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CMap Candidate Details

Structure:
CMap ID: C01983
Pert ID: BRD-K63550407
Compound Name: erythromycin
Targets: MLNR
MoA: NFkB pathway inhibitor
SMILES: CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4584 BRD-K63550407 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
5104 BRD-K63550407 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37179 BRD-K63550407 A375 10 uM 6 h -0.24 -0.99 0.14 0.0 0.0 0.0
37931 BRD-K63550407 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
38531 BRD-K63550407 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38758 BRD-K63550407 PHH 10 uM 24 h 0.0 0.0 0.0 -0.31 -1.05 0.69
38984 BRD-K63550407 SKB 10 uM 24 h -0.29 -1.2 0.56 -0.34 -1.13 0.99
124656 BRD-K63550407 HELA 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124721 BRD-K63550407 JURKAT 10 uM 24 h 0.0 0.0 0.0 -0.26 -0.88 0.25
124742 BRD-K63550407 MCF10A 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124759 BRD-K63550407 MCF??7.00 0.04 uM 24 h 0.0 0.0 0.0 -0.35 -1.17 1.12
124792 BRD-K63550407 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.34 1.21 1.13
124833 BRD-K63550407 PC3 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132685 BRD-K63550407 A549 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132718 BRD-K63550407 HA1E 0.03 uM 24 h 0.26 1.09 0.23 0.0 0.0 0.0
132749 BRD-K63550407 HEK293 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132808 BRD-K63550407 HT29 0.03 uM 24 h -0.32 -1.34 0.98 -0.22 -0.73 0.04
132930 BRD-K63550407 THP1 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132949 BRD-K63550407 YAPC 2.22 uM 24 h 0.0 0.0 0.0 0.29 1.04 0.53
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).