CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C01985
Pert ID:	BRD-K51677086
Compound Name:	erythromycin-ethylsuccinate
Targets:	ABCB1\|ALB\|CYP3A4\|CYP51A1\|KCNH2\|MLNR\|SLC47A1
MoA:	cytochrome P450 inhibitor; protein synthesis inhibitor
SMILES:	CCOC(=O)CCC(=O)O[C@H]1[C@H](O[C@@H]2[C@@H](C)[C@H](O[C@H]3C[C@@](C)(OC)[C@@H](O)[C@H](C)O3)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@]2(C)O)O[C@H](C)C[C@@H]1N(C)C
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
5644	BRD-K51677086	HCC515	10 uM	24 h	0.21	0.86	0.01	-0.2	-0.69	0.02
6373	BRD-K51677086	VCAP	10 uM	24 h	0.0	0.0	0.0	-0.34	-1.13	1.0
44986	BRD-K51677086	ASC	10 uM	24 h	0.21	0.89	0.02	0.26	0.93	0.27
45279	BRD-K51677086	HEPG2	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
46102	BRD-K51677086	NPC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
46416	BRD-K51677086	PHH	10 uM	24 h	0.29	1.21	0.46	0.0	0.0	0.0
46741	BRD-K51677086	SKB	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
97298	BRD-K51677086	HAP1	3.33 uM	24 h	-0.23	-0.95	0.09	0.26	0.92	0.25
97361	BRD-K51677086	A375	3.33 uM	24 h	0.0	0.0	0.0	0.3	1.05	0.57
124339	BRD-K51677086	HELA	1.11 uM	24 h	0.26	1.07	0.2	0.0	0.0	0.0
124400	BRD-K51677086	JURKAT	0.125 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
124460	BRD-K51677086	MCF??7.00	3.33 uM	24 h	0.0	0.0	0.0	-0.3	-1.0	0.55
124535	BRD-K51677086	YAPC	1.11 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
132350	BRD-K51677086	A549	0.01 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
132378	BRD-K51677086	HA1E	0.25 uM	24 h	0.0	0.0	0.0	-0.33	-1.1	0.87
132410	BRD-K51677086	HEK293	2.22 uM	24 h	0.0	0.0	0.0	-0.29	-0.98	0.48
132455	BRD-K51677086	HT29	0.74 uM	24 h	-0.22	-0.9	0.04	0.23	0.8	0.08
132483	BRD-K51677086	MCF10A	0.74 uM	24 h	0.0	0.0	0.0	-0.36	-1.2	1.21
132544	BRD-K51677086	MDAMB231	0.08 uM	24 h	0.0	0.0	0.0	0.31	1.1	0.68
132566	BRD-K51677086	PC3	0.74 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
132588	BRD-K51677086	THP1	0.25 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary