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CMap Candidate Details

Structure:
CMap ID: C01989
Pert ID: BRD-K70301876
Compound Name: escitalopram
Targets: ADRA1A|CHRM1|HRH1|SLC6A2|SLC6A3|SLC6A4
MoA: selective serotonin reuptake inhibitor (SSRI)
SMILES: CN(C)CCC[C@]1(OCc2cc(ccc12)C#N)c1ccc(F)cc1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5676 BRD-K70301876 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
5949 BRD-K70301876 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
6584 BRD-K70301876 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37722 BRD-K70301876 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38542 BRD-K70301876 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38766 BRD-K70301876 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91164 BRD-K70301876 HUH7 10 uM 72 h 0.0 0.0 0.0 -0.26 -0.89 0.26
95410 BRD-K70301876 U2OS 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126716 BRD-K70301876 HELA 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126838 BRD-K70301876 MCF??7.00 0.04 uM 24 h -0.2 -0.85 0.01 0.0 0.0 0.0
126884 BRD-K70301876 MDAMB231 0.37 uM 24 h 0.0 0.0 0.0 0.29 1.03 0.51
126949 BRD-K70301876 THP1 1.11 uM 24 h 0.0 0.0 0.0 -0.32 -1.07 0.76
126994 BRD-K70301876 YAPC 1.11 uM 24 h 0.0 0.0 0.0 0.24 0.83 0.12
134676 BRD-K70301876 A375 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134699 BRD-K70301876 A549 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134728 BRD-K70301876 HA1E 0.03 uM 24 h 0.0 0.0 0.0 -0.32 -1.07 0.75
134765 BRD-K70301876 HEK293 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134825 BRD-K70301876 HT29 0.25 uM 24 h 0.25 1.05 0.17 0.0 0.0 0.0
134864 BRD-K70301876 HUVEC 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134899 BRD-K70301876 JURKAT 0.08 uM 24 h 0.27 1.12 0.26 0.0 0.0 0.0
134926 BRD-K70301876 MCF10A 0.01 uM 24 h 0.0 0.0 0.0 -0.36 -1.2 1.21
134964 BRD-K70301876 PC3 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).