CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C01994
Pert ID:	BRD-A07395371
Compound Name:	esmolol
Targets:	ADRB1
MoA:	adrenergic receptor antagonist
SMILES:	COC(=O)CCc1ccc(OCC(O)CNC(C)C)cc1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
25464	BRD-A07395371	VCAP	10 uM	6 h	0.24	0.99	0.1	0.2	0.71	0.02
91483	BRD-A07395371	HUH7	12 uM	72 h	0.0	0.0	0.0	0.42	1.5	2.27
122554	BRD-A07395371	A375	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
122583	BRD-A07395371	A549	10 uM	24 h	0.0	0.0	0.0	-0.28	-0.93	0.34
122605	BRD-A07395371	HA1E	0.37 uM	24 h	0.24	1.0	0.11	0.0	0.0	0.0
122640	BRD-A07395371	HEK293	0.04 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
122732	BRD-A07395371	MCF10A	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
122799	BRD-A07395371	PC3	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
122820	BRD-A07395371	YAPC	10 uM	24 h	0.0	0.0	0.0	-0.29	-0.97	0.45
130974	BRD-A07395371	HELA	2.22 uM	24 h	0.0	0.0	0.0	-0.32	-1.07	0.77
131005	BRD-A07395371	HT29	0.25 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
131054	BRD-A07395371	HUVEC	0.03 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
131089	BRD-A07395371	MCF??7.00	0.74 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
131127	BRD-A07395371	MDAMB231	0.03 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary