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CMap Candidate Details

Structure:
CMap ID: C02002
Pert ID: BRD-A70858459
Compound Name: estramustine
Targets: ESR1|ESR2|MAP1A|MAP2
MoA: DNA alkylating agent
SMILES: C[C@]12CCC3C(CCc4cc(OC(=O)N(CCCl)CCCl)ccc34)C1CC[C@@H]2O
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
126362 BRD-A70858459 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126400 BRD-A70858459 HA1E 10 uM 24 h 0.0 0.0 0.0 -0.35 -1.18 1.15
126434 BRD-A70858459 HEK293 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126475 BRD-A70858459 HELA 10 uM 24 h 0.23 0.94 0.06 -0.47 -1.59 15.65
126493 BRD-A70858459 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126538 BRD-A70858459 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.39 -1.31 1.71
126600 BRD-A70858459 YAPC 10 uM 24 h -0.22 -0.91 0.05 -0.31 -1.05 0.72
134374 BRD-A70858459 A549 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134500 BRD-A70858459 HUVEC 0.08 uM 24 h 0.21 0.88 0.01 0.21 0.73 0.03
134537 BRD-A70858459 MCF10A 0.03 uM 24 h 0.31 1.28 0.64 0.0 0.0 0.0
134596 BRD-A70858459 MDAMB231 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134624 BRD-A70858459 PC3 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).