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CMap Candidate Details

Structure:
CMap ID: C02008
Pert ID: BRD-K63630713
Compound Name: etacrynic-acid
Targets: ATP1A1|SLC12A1
MoA: sodium/potassium/chloride transporter inhibitor
SMILES: CCC(=C)C(=O)c1ccc(OCC(O)=O)c(Cl)c1Cl
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
6794 BRD-K63630713 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
7704 BRD-K63630713 HCC515 10 uM 6 h 0.0 0.0 0.0 -0.35 -1.19 1.16
8020 BRD-K63630713 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
8718 BRD-K63630713 VCAP 10 uM 24 h 0.0 0.0 0.0 -0.41 -1.39 2.02
91152 BRD-K63630713 HUH7 10 uM 72 h 0.26 1.09 0.22 0.0 0.0 0.0
124638 BRD-K63630713 HEK293 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124723 BRD-K63630713 JURKAT 0.125 uM 24 h 0.0 0.0 0.0 0.18 0.66 0.01
124760 BRD-K63630713 MCF??7.00 10 uM 24 h 0.22 0.9 0.03 0.0 0.0 0.0
124795 BRD-K63630713 MDAMB231 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124836 BRD-K63630713 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124878 BRD-K63630713 THP1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132687 BRD-K63630713 A549 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132719 BRD-K63630713 HA1E 0.01 uM 24 h -0.22 -0.9 0.04 0.23 0.83 0.12
132787 BRD-K63630713 HELA 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132867 BRD-K63630713 MCF10A 2.22 uM 24 h -0.32 -1.35 0.98 0.0 0.0 0.0
132950 BRD-K63630713 YAPC 0.74 uM 24 h 0.28 1.15 0.34 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).