CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C02074
Pert ID:	BRD-K71603915
Compound Name:	EVP-6124
Targets:	CHRNA7
MoA:	acetylcholine receptor agonist
SMILES:	Clc1cccc2cc(sc12)C(=O)N[C@H]1CN2CCC1CC2
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
96297	BRD-K71603915	A375	1.11 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
96369	BRD-K71603915	PC3	10 uM	24 h	0.23	0.94	0.06	0.0	0.0	0.0
126656	BRD-K71603915	A549	10 uM	24 h	0.2	0.85	0.01	0.0	0.0	0.0
126810	BRD-K71603915	MCF10A	10 uM	24 h	-0.22	-0.93	0.07	0.0	0.0	0.0
126852	BRD-K71603915	MCF??7.00	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
126896	BRD-K71603915	MDAMB231	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
126964	BRD-K71603915	THP1	3.33 uM	24 h	-0.28	-1.17	0.5	0.26	0.94	0.28
134738	BRD-K71603915	HA1E	0.74 uM	24 h	0.0	0.0	0.0	-0.24	-0.82	0.15
134773	BRD-K71603915	HEK293	0.08 uM	24 h	0.0	0.0	0.0	0.3	1.08	0.65
134802	BRD-K71603915	HELA	0.74 uM	24 h	0.22	0.92	0.04	0.0	0.0	0.0
134832	BRD-K71603915	HT29	2.22 uM	24 h	-0.25	-1.05	0.22	0.0	0.0	0.0
134878	BRD-K71603915	HUVEC	0.03 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
134904	BRD-K71603915	JURKAT	0.01 uM	24 h	0.0	0.0	0.0	0.27	0.96	0.33
134997	BRD-K71603915	YAPC	2.22 uM	24 h	0.0	0.0	0.0	-0.34	-1.15	1.07

Summary