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CMap Candidate Details

Structure:
CMap ID: C02099
Pert ID: BRD-K08998509
Compound Name: fananserin
Targets: HTR2A
MoA: dopamine receptor antagonist; serotonin receptor antagonist
SMILES: Fc1ccc(cc1)N1CCN(CCCN2c3cccc4cccc(c34)S2(=O)=O)CC1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4054 BRD-K08998509 HA1E 10 uM 24 h 0.0 0.0 0.0 0.32 1.15 0.87
4355 BRD-K08998509 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
4643 BRD-K08998509 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
4889 BRD-K08998509 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
44300 BRD-K08998509 A375 10 uM 6 h -0.28 -1.16 0.46 -0.32 -1.06 0.73
44668 BRD-K08998509 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
44848 BRD-K08998509 ASC 10 uM 24 h 0.0 0.0 0.0 -0.31 -1.05 0.69
45157 BRD-K08998509 HEPG2 10 uM 6 h -0.24 -1.01 0.16 -0.42 -1.4 2.02
45424 BRD-K08998509 HT29 10 uM 6 h 0.0 0.0 0.0 -0.21 -0.7 0.03
45648 BRD-K08998509 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
45963 BRD-K08998509 NPC 10 uM 24 h -0.27 -1.14 0.42 -0.26 -0.87 0.22
46598 BRD-K08998509 SKB 10 uM 24 h -0.25 -1.03 0.2 0.0 0.0 0.0
100043 BRD-K08998509 U2OS 10 uM 6 h -0.21 -0.86 0.02 -0.23 -0.78 0.09
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).