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CMap Candidate Details

Structure:
CMap ID: C00230
Pert ID: BRD-K83988098
Compound Name: alvespimycin
Targets: HSP90AA1
MoA: HSP inhibitor
SMILES: CO[C@H]1C[C@H](C)CC2=C(NCCN(C)C)C(=O)C=C(NC(=O)\C(C)=C\C=C/[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1O)C2=O
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
33713 BRD-K83988098 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
33938 BRD-K83988098 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
34193 BRD-K83988098 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
34434 BRD-K83988098 HA1E 10 uM 6 h 0.0 0.0 0.0 -0.27 -0.9 0.29
34700 BRD-K83988098 HCC515 10 uM 6 h -0.19 -0.8 0.0 0.0 0.0 0.0
34977 BRD-K83988098 HEPG2 10 uM 6 h 0.0 0.0 0.0 -0.24 -0.8 0.12
35216 BRD-K83988098 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
35480 BRD-K83988098 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 -0.37 -1.25 1.35
35627 BRD-K83988098 NEU 10 uM 24 h -0.24 -0.99 0.13 0.3 1.05 0.57
35851 BRD-K83988098 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36110 BRD-K83988098 PC3 10 uM 6 h -0.17 -0.72 0.0 -0.3 -1.0 0.55
36367 BRD-K83988098 PHH 10 uM 24 h 0.24 1.0 0.1 0.33 1.17 0.97
36665 BRD-K83988098 SKB 10 uM 24 h 0.36 1.5 1.42 0.33 1.19 1.01
37012 BRD-K83988098 VCAP 10 uM 6 h 0.24 0.99 0.1 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).