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CMap Candidate Details

Structure:
CMap ID: C02318
Pert ID: BRD-K67578145
Compound Name: GDC-0879
Targets: BRAF
MoA: RAF inhibitor
SMILES: OCCn1cc(c(n1)-c1ccncc1)-c1ccc2c(CC\C2=N/O)c1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
35603 BRD-K67578145 NEU 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
35985 BRD-K67578145 PC3 10 uM 24 h 0.0 0.0 0.0 -0.36 -1.21 1.24
36320 BRD-K67578145 PHH 10 uM 24 h 0.32 1.35 0.94 -0.25 -0.86 0.2
36618 BRD-K67578145 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36991 BRD-K67578145 VCAP 10 uM 6 h 0.0 0.0 0.0 -0.35 -1.18 1.14
91823 BRD-K67578145 HS578T 2.22 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91848 BRD-K67578145 MCF10A 0.08 uM 24 h 0.0 0.0 0.0 -0.25 -0.85 0.19
91899 BRD-K67578145 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91944 BRD-K67578145 SKBR3 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94486 BRD-K67578145 ASC 3.33 uM 24 h -0.22 -0.91 0.05 -0.28 -0.96 0.43
94555 BRD-K67578145 CD34 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94646 BRD-K67578145 HEK293 10 uM 24 h 0.0 0.0 0.0 0.3 1.06 0.6
94695 BRD-K67578145 HELA 10 uM 24 h -0.17 -0.72 0.0 0.0 0.0 0.0
94750 BRD-K67578145 HME1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94842 BRD-K67578145 HUVEC 1.11 uM 24 h 0.2 0.85 0.01 -0.31 -1.03 0.64
94895 BRD-K67578145 JURKAT 3.33 uM 24 h 0.0 0.0 0.0 -0.3 -1.01 0.56
94979 BRD-K67578145 MCF??7.00 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95080 BRD-K67578145 NPC 10 uM 24 h 0.0 0.0 0.0 -0.34 -1.14 1.01
95168 BRD-K67578145 SHSY5Y 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95212 BRD-K67578145 SKL 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95278 BRD-K67578145 THP1 10 uM 24 h 0.0 0.0 0.0 0.33 1.16 0.9
116670 BRD-K67578145 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
116712 BRD-K67578145 A549 0.04 uM 24 h 0.0 0.0 0.0 -0.32 -1.06 0.75
116752 BRD-K67578145 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
116800 BRD-K67578145 HCC515 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
116844 BRD-K67578145 HEPG2 10 uM 24 h 0.0 0.0 0.0 0.31 1.1 0.7
116891 BRD-K67578145 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).