CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C02342
Pert ID:	BRD-K97472745
Compound Name:	gestrinone
Targets:	AR\|ESR1\|PGR
MoA:	progesterone receptor antagonist
SMILES:	CC[C@]12C=CC3=C4CCC(=O)C=C4CC[C@H]3[C@@H]1CC[C@@]2(O)C#C
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
91096	BRD-K97472745	HUH7	10 uM	72 h	-0.17	-0.71	0.0	0.0	0.0	0.0
95369	BRD-K97472745	MCF??7.00	10 uM	48 h	0.0	0.0	0.0	0.0	0.0	0.0
95478	BRD-K97472745	U2OS	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
128404	BRD-K97472745	A549	0.37 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
128466	BRD-K97472745	HEK293	0.04 uM	24 h	0.2	0.84	0.0	-0.29	-0.97	0.46
128490	BRD-K97472745	HELA	10 uM	24 h	0.23	0.96	0.08	-0.27	-0.9	0.29
128576	BRD-K97472745	JURKAT	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
128668	BRD-K97472745	MDAMB231	10 uM	24 h	0.29	1.21	0.47	0.0	0.0	0.0
128747	BRD-K97472745	THP1	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
128786	BRD-K97472745	YAPC	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
136202	BRD-K97472745	A375	0.74 uM	24 h	0.22	0.9	0.02	0.3	1.08	0.65
136246	BRD-K97472745	HA1E	0.03 uM	24 h	0.25	1.04	0.16	0.36	1.29	1.47
136301	BRD-K97472745	HT29	0.01 uM	24 h	-0.23	-0.98	0.12	0.0	0.0	0.0
136325	BRD-K97472745	MCF10A	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
136376	BRD-K97472745	PC3	0.08 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary