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CMap Candidate Details

Structure:
CMap ID: C02354
Pert ID: BRD-K13810148
Compound Name: givinostat
Targets: HDAC1|HDAC2|HDAC3|HDAC4|HDAC5|HDAC6|HDAC7|HDAC8|HDAC9
MoA: HDAC inhibitor
SMILES: CCN(CC)Cc1ccc2cc(COC(=O)Nc3ccc(cc3)C(=O)NO)ccc2c1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
26075 BRD-K13810148 A549 10 uM 6 h 0.23 0.94 0.06 0.0 0.0 0.0
26273 BRD-K13810148 ASC 10 uM 24 h -0.3 -1.27 0.74 -0.45 -1.52 15.35
26610 BRD-K13810148 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
26922 BRD-K13810148 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
27233 BRD-K13810148 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
27677 BRD-K13810148 MCF??7.00 10 uM 6 h -0.2 -0.84 0.0 0.0 0.0 0.0
27857 BRD-K13810148 NEU 10 uM 24 h -0.21 -0.86 0.02 0.31 1.09 0.67
28450 BRD-K13810148 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
28807 BRD-K13810148 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
29124 BRD-K13810148 SKB 10 uM 24 h 0.0 0.0 0.0 0.35 1.24 1.27
29608 BRD-K13810148 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
97300 BRD-K13810148 HAP1 0.66 uM 24 h 0.21 0.86 0.01 0.0 0.0 0.0
97350 BRD-K13810148 A375 0.66 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).