CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C02387
Pert ID:	BRD-K99504665
Compound Name:	goserelin-acetate
Targets:	GNRHR\|LHCGR
MoA:	gonadotropin releasing factor hormone receptor agonist
SMILES:	CC(C)C[C@H](NC(=O)[C@@H](COC(C)(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)NNC(N)=O
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
90965	BRD-K99504665	HUH7	2.5 uM	72 h	-0.21	-0.87	0.02	-0.18	-0.61	0.0
128117	BRD-K99504665	A375	0.125 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
128147	BRD-K99504665	A549	0.37 uM	24 h	-0.35	-1.48	1.43	0.0	0.0	0.0
128190	BRD-K99504665	HT29	1.11 uM	24 h	0.0	0.0	0.0	-0.21	-0.7	0.03
128236	BRD-K99504665	MCF10A	3.33 uM	24 h	0.24	1.02	0.12	-0.27	-0.92	0.33
128315	BRD-K99504665	MDAMB231	0.04 uM	24 h	0.19	0.79	0.0	-0.24	-0.82	0.15
128337	BRD-K99504665	PC3	0.04 uM	24 h	0.33	1.38	0.97	0.0	0.0	0.0
128359	BRD-K99504665	THP1	0.04 uM	24 h	0.0	0.0	0.0	-0.31	-1.04	0.68
135820	BRD-K99504665	HA1E	0.74 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
135860	BRD-K99504665	HEK293	0.01 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
135909	BRD-K99504665	HELA	0.74 uM	24 h	0.0	0.0	0.0	0.25	0.9	0.21
135999	BRD-K99504665	JURKAT	0.01 uM	24 h	-0.31	-1.31	0.82	-0.26	-0.88	0.25
136034	BRD-K99504665	MCF??7.00	2.22 uM	24 h	0.24	0.99	0.1	0.0	0.0	0.0
136145	BRD-K99504665	YAPC	0.03 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary