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CMap Candidate Details

Structure:
CMap ID: C02408
Pert ID: BRD-K24943235
Compound Name: grazoprevir
Targets:
MoA: HCV inhibitor
SMILES: COc1ccc2nc3CCCCC[C@@H]4C[C@H]4OC(=O)N[C@H](C(=O)N4C[C@@H](C[C@H]4C(=O)N[C@@]4(C[C@H]4C=C)C(=O)NS(=O)(=O)C4CC4)Oc3nc2c1)C(C)(C)C
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
120874 BRD-K24943235 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120894 BRD-K24943235 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120972 BRD-K24943235 HEK293 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121004 BRD-K24943235 HELA 10 uM 3 h 0.0 0.0 0.0 0.35 1.23 1.19
121022 BRD-K24943235 HT29 10 uM 24 h 0.0 0.0 0.0 -0.25 -0.86 0.21
121059 BRD-K24943235 MCF??7.00 3.33 uM 24 h 0.23 0.98 0.09 0.0 0.0 0.0
121129 BRD-K24943235 YAPC 10 uM 24 h 0.0 0.0 0.0 0.36 1.27 1.34
129142 BRD-K24943235 HA1E 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129231 BRD-K24943235 PC3 0.74 uM 24 h 0.0 0.0 0.0 -0.27 -0.91 0.3
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).