CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C00242
Pert ID:	BRD-K70330367
Compound Name:	amantadine
Targets:	DRD2\|GRIN2A\|GRIN2B\|GRIN2C\|GRIN2D\|GRIN3A
MoA:	glutamate receptor antagonist
SMILES:	NC12CC3CC(CC(C3)C1)C2
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
4591	BRD-K70330367	HCC515	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
4954	BRD-K70330367	VCAP	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
37724	BRD-K70330367	ASC	10 uM	24 h	0.0	0.0	0.0	-0.27	-0.9	0.28
38543	BRD-K70330367	NPC	10 uM	24 h	0.0	0.0	0.0	-0.37	-1.23	1.28
38768	BRD-K70330367	PHH	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
38995	BRD-K70330367	SKB	10 uM	24 h	-0.24	-1.01	0.15	0.21	0.73	0.03
126357	BRD-K70330367	A375	0.04 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
126426	BRD-K70330367	HEK293	0.04 uM	24 h	0.0	0.0	0.0	-0.21	-0.72	0.04
126516	BRD-K70330367	MCF10A	1.11 uM	24 h	-0.32	-1.34	0.98	0.19	0.68	0.01
134370	BRD-K70330367	A549	0.03 uM	24 h	-0.33	-1.36	1.06	0.0	0.0	0.0
134393	BRD-K70330367	HA1E	0.08 uM	24 h	0.0	0.0	0.0	-0.23	-0.79	0.1
134423	BRD-K70330367	HELA	0.08 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
134455	BRD-K70330367	HT29	0.08 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
134563	BRD-K70330367	MCF??7.00	0.03 uM	24 h	-0.21	-0.86	0.02	0.0	0.0	0.0
134592	BRD-K70330367	MDAMB231	0.74 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
134619	BRD-K70330367	PC3	0.01 uM	24 h	0.0	0.0	0.0	-0.18	-0.62	0.0
134648	BRD-K70330367	YAPC	0.74 uM	24 h	-0.21	-0.88	0.03	-0.31	-1.03	0.63

Summary