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CMap Candidate Details

Structure:
CMap ID: C02433
Pert ID: BRD-K04833372
Compound Name: GSK1904529A
Targets: IGF1R|INSR
MoA: IGF-1 inhibitor; insulin growth factor receptor inhibitor; insulin receptor ligand
SMILES: CCc1cc(Nc2nccc(n2)-c2c(nc3ccccn23)-c2ccc(OC)c(c2)C(=O)Nc2c(F)cccc2F)c(OC)cc1N1CCC(CC1)N1CCN(CC1)S(C)(=O)=O
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
30341 BRD-K04833372 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
30947 BRD-K04833372 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
31247 BRD-K04833372 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
31984 BRD-K04833372 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
32332 BRD-K04833372 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
32926 BRD-K04833372 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
33234 BRD-K04833372 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92410 BRD-K04833372 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92467 BRD-K04833372 BT20 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92502 BRD-K04833372 HA1E 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92536 BRD-K04833372 HME1 10 uM 24 h -0.29 -1.2 0.55 0.28 0.99 0.41
92582 BRD-K04833372 HS578T 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92630 BRD-K04833372 HT29 10 uM 24 h 0.0 0.0 0.0 0.18 0.65 0.0
92695 BRD-K04833372 LNCAP 0.12 uM 3 h 0.0 0.0 0.0 -0.25 -0.84 0.17
92737 BRD-K04833372 MCF10A 10 uM 3 h -0.31 -1.29 0.8 0.0 0.0 0.0
92789 BRD-K04833372 MDAMB231 10 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
92806 BRD-K04833372 PC3 0.04 uM 24 h 0.0 0.0 0.0 -0.32 -1.07 0.75
92828 BRD-K04833372 SKBR3 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
96106 BRD-K04833372 A549 10 uM 24 h -0.23 -0.95 0.09 0.22 0.77 0.06
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).