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CMap Candidate Details

Structure:
CMap ID: C02454
Pert ID: BRD-K92428232
Compound Name: GSK461364
Targets: PLK1
MoA: PLK inhibitor
SMILES: C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2ccc(CN3CCN(C)CC3)cc12)c1ccccc1C(F)(F)F
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
57 BRD-K92428232 BJAB 10 uM 4 h 0.26 1.08 0.22 0.0 0.0 0.0
91 BRD-K92428232 HBL1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
152 BRD-K92428232 K562 10 uM 4 h 0.0 0.0 0.0 0.0 0.0 0.0
180 BRD-K92428232 KMS34 10 uM 24 h 0.0 0.0 0.0 0.33 1.18 0.97
221 BRD-K92428232 NALM6 2.5 uM 24 h -0.22 -0.92 0.06 0.26 0.91 0.23
260 BRD-K92428232 OCILY10 2.5 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
287 BRD-K92428232 OCILY19 2.5 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
335 BRD-K92428232 OCILY3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
379 BRD-K92428232 SKMEL5 2.5 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
464 BRD-K92428232 TMD8 10 uM 4 h 0.26 1.1 0.24 0.0 0.0 0.0
33170 BRD-K92428232 SKB 10 uM 24 h 0.0 0.0 0.0 -0.28 -0.96 0.42
33373 BRD-K92428232 VCAP 10 uM 24 h 0.0 0.0 0.0 0.26 0.93 0.27
91558 BRD-K92428232 BT20 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91588 BRD-K92428232 HS578T 10 uM 24 h 0.0 0.0 0.0 -0.35 -1.17 1.13
91718 BRD-K92428232 MDAMB231 10 uM 6 h -0.24 -1.0 0.15 0.0 0.0 0.0
91731 BRD-K92428232 SKBR3 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93679 BRD-K92428232 ASC 10 uM 24 h 0.0 0.0 0.0 0.3 1.05 0.58
93692 BRD-K92428232 CD34 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93779 BRD-K92428232 HCC515 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93818 BRD-K92428232 HEK293 10 uM 24 h 0.0 0.0 0.0 0.19 0.69 0.01
93978 BRD-K92428232 HUVEC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94085 BRD-K92428232 NEU 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94131 BRD-K92428232 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94215 BRD-K92428232 SHSY5Y 0.04 uM 24 h 0.21 0.87 0.01 -0.24 -0.82 0.15
94268 BRD-K92428232 SKL 10 uM 24 h 0.0 0.0 0.0 -0.35 -1.16 1.11
95614 BRD-K92428232 U2OS 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
96857 BRD-K92428232 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
118866 BRD-K92428232 HEPG2 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
118908 BRD-K92428232 HT29 3.33 uM 24 h -0.25 -1.05 0.24 0.0 0.0 0.0
118977 BRD-K92428232 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128367 BRD-K92428232 A549 1.11 uM 24 h 0.23 0.96 0.07 0.0 0.0 0.0
128469 BRD-K92428232 HELA 0.04 uM 24 h 0.0 0.0 0.0 -0.42 -1.42 2.16
128525 BRD-K92428232 JURKAT 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128581 BRD-K92428232 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128607 BRD-K92428232 MCF??7.00 10 uM 24 h 0.18 0.75 0.0 0.32 1.15 0.88
128698 BRD-K92428232 THP1 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128751 BRD-K92428232 YAPC 0.37 uM 24 h -0.22 -0.93 0.07 0.33 1.18 0.98
136206 BRD-K92428232 HA1E 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).