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CMap Candidate Details

Structure:
CMap ID: C02559
Pert ID: BRD-K76674262
Compound Name: homoharringtonine
Targets: RPL3
MoA: protein synthesis inhibitor
SMILES: COC(=O)C[C@](O)(CCCC(C)(C)O)C(=O)O[C@H]1[C@H]2c3cc4OCOc4cc3CCN3CCC[C@]23C=C1OC
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1146 BRD-K76674262 A549 1.11 uM 24 h 0.0 0.0 0.0 -0.3 -1.02 0.61
1182 BRD-K76674262 PC3 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
1372 BRD-K76674262 U2OS 1.11 uM 48 h 0.0 0.0 0.0 0.0 0.0 0.0
2124 BRD-K76674262 HCC515 10 uM 6 h 0.3 1.23 0.5 -0.49 -1.64 15.65
41841 BRD-K76674262 A375 10 uM 6 h 0.33 1.36 0.97 -0.51 -1.72 15.65
42473 BRD-K76674262 ASC 10 uM 24 h 0.37 1.53 1.45 -0.43 -1.45 15.35
42783 BRD-K76674262 HEPG2 10 uM 6 h 0.33 1.37 0.97 -0.5 -1.67 15.65
43950 BRD-K76674262 PHH 10 uM 24 h 0.28 1.15 0.33 -0.39 -1.3 1.57
44202 BRD-K76674262 SKB 10 uM 24 h 0.0 0.0 0.0 -0.52 -1.76 15.65
53610 BRD-K76674262 HUH7 10 uM 6 h 0.25 1.04 0.15 -0.47 -1.58 15.65
119695 BRD-K76674262 HT29 0.04 uM 24 h 0.19 0.8 0.0 0.0 0.0 0.0
119740 BRD-K76674262 JURKAT 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127439 BRD-K76674262 HA1E 0.04 uM 24 h 0.37 1.56 1.48 0.0 0.0 0.0
127702 BRD-K76674262 YAPC 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135377 BRD-K76674262 HELA 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135446 BRD-K76674262 MCF10A 0.03 uM 24 h 0.0 0.0 0.0 -0.27 -0.9 0.28
135479 BRD-K76674262 MCF??7.00 0.01 uM 24 h 0.0 0.0 0.0 0.24 0.84 0.13
135504 BRD-K76674262 THP1 0.03 uM 24 h 0.0 0.0 0.0 -0.33 -1.12 0.94
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).