CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C02581
Pert ID:	BRD-K36862742
Compound Name:	hydroflumethiazide
Targets:	ATP1A1\|CA1\|CA12\|CA2\|CA4\|CA9\|KCNMA1\|SLC12A1\|SLC12A3
MoA:	sodium/potassium/chloride transporter inhibitor
SMILES:	NS(=O)(=O)c1cc2c(NCNS2(=O)=O)cc1C(F)(F)F
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
50003	BRD-K36862742	A549	10 uM	6 h	0.0	0.0	0.0	-0.3	-1.0	0.55
50355	BRD-K36862742	HCC515	10 uM	6 h	-0.18	-0.74	0.0	0.0	0.0	0.0
51028	BRD-K36862742	VCAP	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
121732	BRD-K36862742	HA1E	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
121756	BRD-K36862742	HELA	1.11 uM	24 h	0.0	0.0	0.0	-0.32	-1.07	0.76
121786	BRD-K36862742	HT29	0.37 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
121836	BRD-K36862742	PC3	0.04 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
129750	BRD-K36862742	A375	0.25 uM	24 h	0.0	0.0	0.0	-0.23	-0.78	0.1
129815	BRD-K36862742	HEK293	0.08 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
129910	BRD-K36862742	JURKAT	0.25 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
129942	BRD-K36862742	MCF10A	0.25 uM	24 h	-0.2	-0.84	0.0	-0.34	-1.15	1.07
129991	BRD-K36862742	MCF??7.00	0.74 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
130026	BRD-K36862742	MDAMB231	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
130098	BRD-K36862742	THP1	0.25 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
130149	BRD-K36862742	YAPC	0.08 uM	24 h	0.25	1.06	0.18	0.0	0.0	0.0

Summary