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CMap Candidate Details

Structure:
CMap ID: C02604
Pert ID: BRD-K08109215
Compound Name: I-BET-762
Targets: BRD2|BRD3|BRD4
MoA: bromodomain inhibitor
SMILES: CCNC(=O)C[C@@H]1N=C(c2ccc(Cl)cc2)c2cc(OC)ccc2-n2c(C)nnc12
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
87287 BRD-K08109215 BJAB 10 uM 24 h 0.27 1.12 0.27 -0.3 -1.02 0.6
87363 BRD-K08109215 HBL1 10 uM 24 h 0.0 0.0 0.0 -0.37 -1.24 1.35
87413 BRD-K08109215 K562 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87461 BRD-K08109215 KMS34 0.66 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87505 BRD-K08109215 MINO 0.04 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
87565 BRD-K08109215 NALM6 2.5 uM 24 h 0.22 0.92 0.04 -0.29 -0.97 0.45
87615 BRD-K08109215 OCILY10 0.125 uM 24 h 0.0 0.0 0.0 -0.34 -1.14 1.01
87666 BRD-K08109215 OCILY19 10 uM 24 h 0.28 1.16 0.35 -0.28 -0.94 0.38
87717 BRD-K08109215 OCILY3 10 uM 24 h 0.0 0.0 0.0 -0.3 -0.99 0.51
87764 BRD-K08109215 SKMEL5 10 uM 24 h 0.0 0.0 0.0 -0.24 -0.82 0.15
87789 BRD-K08109215 THP1 0.66 uM 24 h 0.17 0.7 0.0 0.0 0.0 0.0
87836 BRD-K08109215 TMD8 0.125 uM 24 h 0.0 0.0 0.0 -0.41 -1.38 2.02
90291 BRD-K08109215 VCAP 10 uM 24 h 0.0 0.0 0.0 -0.3 -1.0 0.52
90897 BRD-K08109215 MCF10A 3.33 uM 6 h 0.33 1.37 0.97 0.0 0.0 0.0
93654 BRD-K08109215 ASC 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93715 BRD-K08109215 CD34 10 uM 24 h 0.27 1.14 0.31 0.0 0.0 0.0
93842 BRD-K08109215 HEK293 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93927 BRD-K08109215 HEPG2 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93962 BRD-K08109215 HUVEC 10 uM 24 h 0.32 1.34 0.9 -0.32 -1.09 0.82
94026 BRD-K08109215 JURKAT 3.33 uM 24 h 0.15 0.61 0.0 0.0 0.0 0.0
94105 BRD-K08109215 NEU 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94138 BRD-K08109215 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94238 BRD-K08109215 SHSY5Y 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94290 BRD-K08109215 SKL 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
97283 BRD-K08109215 HAP1 0.66 uM 24 h 0.24 1.01 0.11 0.24 0.85 0.15
97956 BRD-K08109215 P1A82 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
118791 BRD-K08109215 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121175 BRD-K08109215 A549 10 uM 24 h 0.34 1.41 1.03 -0.25 -0.84 0.18
121261 BRD-K08109215 HELA 1.11 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
121300 BRD-K08109215 PC3 0.04 uM 24 h 0.24 1.01 0.12 0.0 0.0 0.0
121339 BRD-K08109215 YAPC 10 uM 24 h 0.29 1.21 0.47 0.0 0.0 0.0
129239 BRD-K08109215 A375 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129252 BRD-K08109215 HA1E 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129285 BRD-K08109215 HT29 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129322 BRD-K08109215 MCF??7.00 2.22 uM 24 h 0.0 0.0 0.0 -0.23 -0.77 0.09
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).