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CMap Candidate Details

Structure:
CMap ID: C02616
Pert ID: BRD-K70301465
Compound Name: ibrutinib
Targets: BLK|BMX|BTK
MoA: Bruton's tyrosine kinase (BTK) inhibitor
SMILES: Nc1ncnc2n(nc(-c3ccc(Oc4ccccc4)cc3)c12)[C@@H]1CCCN(C1)C(=O)C=C
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
77 BRD-K70301465 HBL1 10 uM 24 h 0.0 0.0 0.0 -0.26 -0.88 0.24
87315 BRD-K70301465 BJAB 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
87390 BRD-K70301465 K562 2.5 uM 24 h 0.28 1.16 0.35 0.43 1.53 2.3
87476 BRD-K70301465 KMS34 10 uM 24 h 0.0 0.0 0.0 0.3 1.07 0.63
87491 BRD-K70301465 MINO 10 uM 24 h 0.0 0.0 0.0 -0.18 -0.62 0.0
87541 BRD-K70301465 NALM6 10 uM 24 h 0.0 0.0 0.0 -0.26 -0.87 0.24
87631 BRD-K70301465 OCILY10 2.5 uM 24 h 0.0 0.0 0.0 0.3 1.06 0.59
87680 BRD-K70301465 OCILY19 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87693 BRD-K70301465 OCILY3 10 uM 24 h -0.24 -0.99 0.14 0.38 1.36 1.72
87779 BRD-K70301465 SKMEL5 10 uM 24 h 0.0 0.0 0.0 -0.22 -0.73 0.05
87862 BRD-K70301465 TMD8 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
116012 BRD-K70301465 A549 10 uM 24 h 0.0 0.0 0.0 0.27 0.94 0.3
116093 BRD-K70301465 HCC515 10 uM 24 h 0.0 0.0 0.0 0.43 1.51 2.28
116138 BRD-K70301465 HEPG2 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
116184 BRD-K70301465 HT29 3.33 uM 24 h 0.0 0.0 0.0 -0.3 -1.0 0.54
116222 BRD-K70301465 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126629 BRD-K70301465 A375 10 uM 24 h 0.21 0.87 0.01 0.0 0.0 0.0
126690 BRD-K70301465 HEK293 10 uM 24 h 0.24 0.99 0.1 -0.35 -1.17 1.14
126714 BRD-K70301465 HELA 10 uM 24 h 0.0 0.0 0.0 0.38 1.35 1.72
126773 BRD-K70301465 JURKAT 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126945 BRD-K70301465 THP1 10 uM 24 h -0.2 -0.83 0.0 -0.33 -1.11 0.92
126991 BRD-K70301465 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134725 BRD-K70301465 HA1E 2.22 uM 24 h 0.2 0.82 0.0 -0.38 -1.28 1.45
134860 BRD-K70301465 HUVEC 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134923 BRD-K70301465 MCF10A 2.22 uM 24 h 0.0 0.0 0.0 0.25 0.88 0.18
134940 BRD-K70301465 MDAMB231 2.22 uM 24 h 0.21 0.9 0.02 -0.32 -1.08 0.79
134960 BRD-K70301465 PC3 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).