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CMap Candidate Details

Structure:
CMap ID: C02628
Pert ID: BRD-K65639003
Compound Name: icariin
Targets: PDE5A
MoA: phosphodiesterase inhibitor
SMILES: COc1ccc(cc1)-c1oc2c(CC=C(C)C)c(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)cc(O)c2c(=O)c1O[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5225 BRD-K65639003 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
5475 BRD-K65639003 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
5797 BRD-K65639003 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
6581 BRD-K65639003 VCAP 10 uM 6 h 0.0 0.0 0.0 -0.3 -1.01 0.58
25103 BRD-K65639003 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 -0.33 -1.11 0.89
25258 BRD-K65639003 PC3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
42128 BRD-K65639003 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
42435 BRD-K65639003 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
42750 BRD-K65639003 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
43049 BRD-K65639003 HT29 10 uM 6 h -0.25 -1.02 0.18 0.0 0.0 0.0
43615 BRD-K65639003 NPC 10 uM 24 h 0.0 0.0 0.0 -0.24 -0.81 0.12
99344 BRD-K65639003 U2OS 10 uM 6 h 0.0 0.0 0.0 0.23 0.82 0.1
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).