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CMap Candidate Details

Structure:
CMap ID: C02670
Pert ID: BRD-K51662849
Compound Name: ilomastat
Targets: ACAN|ADAM28|MMP1|MMP12|MMP13|MMP14|MMP2|MMP3|MMP8|MMP9
MoA: matrix metalloprotease inhibitor
SMILES: CNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)CC(=O)NO
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
6428 BRD-K51662849 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
44985 BRD-K51662849 ASC 10 uM 24 h 0.23 0.95 0.06 0.0 0.0 0.0
45832 BRD-K51662849 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
46101 BRD-K51662849 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
46740 BRD-K51662849 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
118071 BRD-K51662849 A549 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
118157 BRD-K51662849 HCC515 10 uM 24 h 0.0 0.0 0.0 0.34 1.19 1.03
118205 BRD-K51662849 HEPG2 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124341 BRD-K51662849 HELA 0.125 uM 24 h 0.0 0.0 0.0 -0.3 -1.01 0.57
124378 BRD-K51662849 HT29 10 uM 24 h -0.17 -0.72 0.0 0.0 0.0 0.0
124402 BRD-K51662849 JURKAT 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124479 BRD-K51662849 MDAMB231 10 uM 24 h 0.21 0.87 0.01 -0.31 -1.06 0.72
132321 BRD-K51662849 A375 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132380 BRD-K51662849 HA1E 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132412 BRD-K51662849 HEK293 2.22 uM 24 h 0.21 0.9 0.02 0.0 0.0 0.0
132485 BRD-K51662849 MCF10A 2.22 uM 24 h -0.25 -1.04 0.21 0.28 0.98 0.37
132567 BRD-K51662849 PC3 2.22 uM 24 h 0.0 0.0 0.0 0.36 1.27 1.34
132590 BRD-K51662849 THP1 2.22 uM 24 h 0.0 0.0 0.0 0.28 0.98 0.37
132637 BRD-K51662849 YAPC 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).