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CMap Candidate Details

Structure:
CMap ID: C02673
Pert ID: BRD-K92723993
Compound Name: imatinib
Targets: ABL1|CSF1R|DDR1|KIT|NTRK1|PDGFRA|PDGFRB|RET
MoA: Bcr-Abl kinase inhibitor; KIT inhibitor; PDGFR tyrosine kinase receptor inhibitor
SMILES: CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)CC1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1157 BRD-K92723993 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.07 0.76
1331 BRD-K92723993 U2OS 10 uM 24 h 0.0 0.0 0.0 0.24 0.85 0.14
25445 BRD-K92723993 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
30587 BRD-K92723993 ASC 10 uM 24 h 0.25 1.04 0.15 0.37 1.3 1.49
31164 BRD-K92723993 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
31477 BRD-K92723993 HEPG2 10 uM 6 h 0.0 0.0 0.0 -0.33 -1.12 0.95
33172 BRD-K92723993 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87323 BRD-K92723993 BJAB 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
87348 BRD-K92723993 HBL1 10 uM 24 h 0.0 0.0 0.0 -0.33 -1.11 0.9
87398 BRD-K92723993 K562 10 uM 24 h 0.0 0.0 0.0 0.32 1.14 0.86
87445 BRD-K92723993 KMS34 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87518 BRD-K92723993 MINO 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
87549 BRD-K92723993 NALM6 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87600 BRD-K92723993 OCILY10 0.66 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87650 BRD-K92723993 OCILY19 10 uM 24 h -0.27 -1.12 0.38 0.0 0.0 0.0
87702 BRD-K92723993 OCILY3 2.5 uM 24 h -0.27 -1.14 0.42 -0.35 -1.17 1.14
87749 BRD-K92723993 SKMEL5 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87866 BRD-K92723993 TMD8 10 uM 6 h 0.0 0.0 0.0 -0.32 -1.08 0.81
90956 BRD-K92723993 HUH7 6.66 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
92444 BRD-K92723993 A549 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92482 BRD-K92723993 BT20 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92513 BRD-K92723993 HA1E 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.07 0.76
92546 BRD-K92723993 HME1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92613 BRD-K92723993 HS578T 0.12 uM 3 h 0.0 0.0 0.0 -0.28 -0.94 0.37
92703 BRD-K92723993 LNCAP 10 uM 3 h 0.0 0.0 0.0 -0.27 -0.91 0.3
92752 BRD-K92723993 MCF10A 0.12 uM 3 h -0.26 -1.1 0.35 0.0 0.0 0.0
92839 BRD-K92723993 SKBR3 10 uM 24 h 0.0 0.0 0.0 -0.33 -1.09 0.84
98779 BRD-K92723993 NPC 10 uM 24 h 0.0 0.0 0.0 0.27 0.97 0.36
98951 BRD-K92723993 NEU 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128098 BRD-K92723993 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128277 BRD-K92723993 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135835 BRD-K92723993 HEK293 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135873 BRD-K92723993 HELA 0.25 uM 24 h 0.26 1.06 0.19 0.31 1.09 0.67
135926 BRD-K92723993 HT29 0.01 uM 24 h -0.26 -1.08 0.31 -0.26 -0.88 0.25
135961 BRD-K92723993 JURKAT 0.03 uM 24 h 0.0 0.0 0.0 -0.38 -1.28 1.45
136044 BRD-K92723993 PC3 2.22 uM 24 h -0.19 -0.8 0.0 0.29 1.02 0.48
136076 BRD-K92723993 THP1 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
136107 BRD-K92723993 YAPC 2.22 uM 24 h 0.0 0.0 0.0 0.28 0.99 0.42
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).