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CMap Candidate Details

Structure:
CMap ID: C02676
Pert ID: BRD-A78195072
Compound Name: imexon
Targets: RRM1|RRM2
MoA: apoptosis stimulant; ribonucleotide reductase inhibitor
SMILES: N=C1NC(=O)N2CC12
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
95397 BRD-A78195072 U2OS 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127370 BRD-A78195072 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127447 BRD-A78195072 HA1E 10 uM 24 h -0.26 -1.07 0.27 0.0 0.0 0.0
127491 BRD-A78195072 HT29 0.125 uM 24 h 0.26 1.09 0.23 -0.32 -1.09 0.83
127537 BRD-A78195072 JURKAT 10 uM 24 h 0.0 0.0 0.0 0.26 0.92 0.24
127625 BRD-A78195072 PC3 0.125 uM 24 h -0.26 -1.07 0.27 0.37 1.3 1.58
127710 BRD-A78195072 YAPC 10 uM 24 h -0.21 -0.88 0.03 0.0 0.0 0.0
135352 BRD-A78195072 A549 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135382 BRD-A78195072 HELA 0.03 uM 24 h -0.3 -1.27 0.74 0.34 1.2 1.13
135451 BRD-A78195072 MCF10A 0.03 uM 24 h 0.19 0.8 0.0 0.0 0.0 0.0
135482 BRD-A78195072 MCF??7.00 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135507 BRD-A78195072 THP1 2.22 uM 24 h 0.0 0.0 0.0 0.33 1.17 0.95
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).