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CMap Candidate Details

Structure:
CMap ID: C02699
Pert ID: BRD-K74057757
Compound Name: indibulin
Targets:
MoA: tubulin polymerization inhibitor
SMILES: Clc1ccc(Cn2cc(C(=O)C(=O)Nc3ccncc3)c3ccccc23)cc1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
127353 BRD-K74057757 A375 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127393 BRD-K74057757 A549 3.33 uM 24 h 0.0 0.0 0.0 -0.27 -0.9 0.29
127425 BRD-K74057757 HA1E 0.125 uM 24 h 0.0 0.0 0.0 -0.4 -1.35 2.02
127465 BRD-K74057757 HELA 10 uM 24 h 0.0 0.0 0.0 -0.39 -1.32 1.71
127516 BRD-K74057757 JURKAT 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127555 BRD-K74057757 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127575 BRD-K74057757 MCF??7.00 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127608 BRD-K74057757 PC3 10 uM 24 h -0.22 -0.91 0.05 -0.41 -1.37 2.02
127647 BRD-K74057757 THP1 3.33 uM 24 h 0.23 0.94 0.06 0.0 0.0 0.0
127686 BRD-K74057757 YAPC 10 uM 24 h 0.0 0.0 0.0 -0.31 -1.04 0.68
135403 BRD-K74057757 HT29 0.74 uM 24 h -0.26 -1.09 0.33 -0.4 -1.35 1.87
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).