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CMap Candidate Details

Structure:
CMap ID: C02703
Pert ID: BRD-K19136521
Compound Name: indirubin-3-monoxime
Targets: CDK1|CDK2|CDK5|CDK5R1|GSK3B
MoA: CDK inhibitor; glycogen synthase kinase inhibitor
SMILES: O\N=C1c2ccccc2NC/1=C1\C(=O)Nc2ccccc12
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5306 BRD-K19136521 HA1E 10 uM 24 h 0.32 1.34 0.89 0.0 0.0 0.0
5590 BRD-K19136521 HCC515 10 uM 24 h -0.17 -0.72 0.0 -0.3 -1.01 0.56
6264 BRD-K19136521 PC3 10 uM 6 h 0.0 0.0 0.0 0.27 0.97 0.35
6527 BRD-K19136521 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37130 BRD-K19136521 A375 10 uM 6 h -0.29 -1.2 0.57 0.0 0.0 0.0
37273 BRD-K19136521 A549 10 uM 24 h 0.0 0.0 0.0 -0.28 -0.95 0.4
37609 BRD-K19136521 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37878 BRD-K19136521 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
38061 BRD-K19136521 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
38187 BRD-K19136521 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38439 BRD-K19136521 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38922 BRD-K19136521 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).