CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C02711
Pert ID:	BRD-K57222227
Compound Name:	indomethacin
Targets:	GLO1\|PLA2G2A\|PPARA\|PPARG\|PTGDR2\|PTGR2\|PTGS1\|PTGS2\|SLC46A1
MoA:	cyclooxygenase inhibitor
SMILES:	COc1ccc2n(C(=O)c3ccc(Cl)cc3)c(C)c(CC(O)=O)c2c1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
7184	BRD-K57222227	A549	10 uM	6 h	-0.21	-0.86	0.02	0.0	0.0	0.0
8711	BRD-K57222227	VCAP	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
53035	BRD-K57222227	HEPG2	100 uM	48 h	0.0	0.0	0.0	0.22	0.78	0.06
53117	BRD-K57222227	MCF10A	30 uM	24 h	-0.29	-1.21	0.58	0.0	0.0	0.0
90802	BRD-K57222227	HPTEC	320 uM	6 h	0.18	0.74	0.0	-0.26	-0.88	0.25
91154	BRD-K57222227	HUH7	10 uM	72 h	-0.34	-1.42	1.43	0.0	0.0	0.0
99690	BRD-K57222227	U2OS	15 uM	6 h	-0.24	-1.0	0.14	0.0	0.0	0.0
115414	BRD-K57222227	HCC515	0.04 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
115516	BRD-K57222227	HT29	10 uM	24 h	0.24	1.01	0.12	0.33	1.16	0.9
123561	BRD-K57222227	HEK293	1.11 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
123721	BRD-K57222227	MCF??7.00	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
123740	BRD-K57222227	PC3	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
123760	BRD-K57222227	YAPC	10 uM	24 h	0.22	0.91	0.03	0.0	0.0	0.0
131972	BRD-K57222227	A375	0.08 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
132005	BRD-K57222227	HA1E	0.25 uM	24 h	0.29	1.22	0.48	0.21	0.75	0.04
132030	BRD-K57222227	HELA	0.25 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary