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CMap Candidate Details

Structure:
CMap ID: C02759
Pert ID: BRD-K74195153
Compound Name: irsogladine
Targets: PDE4A
MoA: phosphodiesterase inhibitor
SMILES: Nc1nc(N)nc(n1)-c1cc(Cl)ccc1Cl
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1967 BRD-K74195153 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
25042 BRD-K74195153 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
25418 BRD-K74195153 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
42465 BRD-K74195153 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
43643 BRD-K74195153 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
43942 BRD-K74195153 PHH 10 uM 24 h 0.0 0.0 0.0 0.29 1.02 0.48
44197 BRD-K74195153 SKB 10 uM 24 h -0.2 -0.85 0.01 -0.21 -0.72 0.04
91375 BRD-K74195153 HUH7 12.5 uM 72 h -0.32 -1.34 0.97 0.21 0.74 0.03
99454 BRD-K74195153 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
127011 BRD-K74195153 A375 0.125 uM 24 h -0.26 -1.08 0.3 0.0 0.0 0.0
127272 BRD-K74195153 THP1 0.125 uM 24 h 0.0 0.0 0.0 -0.26 -0.87 0.23
135032 BRD-K74195153 A549 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135076 BRD-K74195153 HA1E 0.74 uM 24 h 0.19 0.79 0.0 0.0 0.0 0.0
135098 BRD-K74195153 HEK293 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135125 BRD-K74195153 HELA 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135143 BRD-K74195153 HT29 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135163 BRD-K74195153 JURKAT 0.74 uM 24 h 0.0 0.0 0.0 -0.36 -1.23 1.25
135197 BRD-K74195153 MCF10A 2.22 uM 24 h 0.0 0.0 0.0 0.24 0.84 0.12
135251 BRD-K74195153 MDAMB231 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135296 BRD-K74195153 PC3 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135322 BRD-K74195153 YAPC 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).