CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C02807
Pert ID:	BRD-K96740444
Compound Name:	itopride
Targets:	CHRM3\|DRD2
MoA:	dopamine receptor antagonist
SMILES:	COc1ccc(cc1OC)C(=O)NCc1ccc(OCCN(C)C)cc1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
24705	BRD-K96740444	A549	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
25547	BRD-K96740444	VCAP	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
91437	BRD-K96740444	HUH7	10 uM	72 h	-0.28	-1.17	0.48	0.0	0.0	0.0
128454	BRD-K96740444	HEK293	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
128484	BRD-K96740444	HELA	3.33 uM	24 h	0.3	1.24	0.51	0.0	0.0	0.0
128512	BRD-K96740444	HT29	10 uM	24 h	0.0	0.0	0.0	-0.4	-1.36	2.02
128564	BRD-K96740444	JURKAT	0.37 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
128656	BRD-K96740444	MDAMB231	0.125 uM	24 h	0.24	1.02	0.13	0.0	0.0	0.0
128689	BRD-K96740444	PC3	1.11 uM	24 h	0.0	0.0	0.0	0.25	0.89	0.21
128736	BRD-K96740444	THP1	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
136193	BRD-K96740444	A375	0.01 uM	24 h	0.0	0.0	0.0	-0.22	-0.73	0.05
136238	BRD-K96740444	HA1E	0.03 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
136318	BRD-K96740444	MCF10A	0.74 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
136350	BRD-K96740444	MCF??7.00	0.74 uM	24 h	0.0	0.0	0.0	-0.33	-1.12	0.95
136390	BRD-K96740444	YAPC	2.22 uM	24 h	0.0	0.0	0.0	-0.37	-1.25	1.35

Summary