CMap Candidate Details
Structure:
| CMap ID: | C02812 |
| Pert ID: | BRD-K31385749 |
| Compound Name: | ivabradine |
| Targets: | HCN1|HCN3|HCN4 |
| MoA: | HCN channel antagonist; potassium channel blocker; sodium channel blocker |
| SMILES: | COc1cc2C[C@@H](CN(C)CCCN3CCc4cc(OC)c(OC)cc4CC3=O)c2cc1OC |
| InchiKey: | |
| Compound Aliases: |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 120511 | BRD-K31385749 | A375 | 0.04 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.31 | 1.11 | 0.71 |
| 120544 | BRD-K31385749 | A549 | 3.33 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 120589 | BRD-K31385749 | HA1E | 0.04 uM | 24 h | 0.19 | 0.79 | 0.0 | 0.32 | 1.14 | 0.86 |
| 120645 | BRD-K31385749 | HT29 | 0.04 uM | 24 h | 0.24 | 1.01 | 0.12 | -0.26 | -0.88 | 0.26 |
| 120695 | BRD-K31385749 | JURKAT | 0.37 uM | 24 h | -0.17 | -0.7 | 0.0 | -0.25 | -0.85 | 0.19 |
| 120801 | BRD-K31385749 | YAPC | 0.04 uM | 24 h | -0.22 | -0.9 | 0.04 | -0.34 | -1.15 | 1.07 |
| 129027 | BRD-K31385749 | HELA | 0.08 uM | 3 h | 0.2 | 0.82 | 0.0 | 0.22 | 0.77 | 0.06 |
| 129047 | BRD-K31385749 | MCF??7.00 | 0.08 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.34 | 1.21 | 1.15 |
| 129075 | BRD-K31385749 | PC3 | 0.01 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |