Logo 1 Logo 2

CMap Candidate Details

Structure:
CMap ID: C02813
Pert ID: BRD-K52818472
Compound Name: ivacaftor
Targets: CFTR
MoA: CFTR channel potentiator
SMILES: CC(C)(C)c1cc(c(NC(=O)c2c[nH]c3ccccc3c2=O)cc1O)C(C)(C)C
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
124273 BRD-K52818472 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124315 BRD-K52818472 HEK293 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124381 BRD-K52818472 HT29 10 uM 24 h 0.0 0.0 0.0 -0.35 -1.17 1.11
124412 BRD-K52818472 JURKAT 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124484 BRD-K52818472 MDAMB231 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124514 BRD-K52818472 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124543 BRD-K52818472 YAPC 0.37 uM 24 h 0.0 0.0 0.0 -0.23 -0.79 0.11
132354 BRD-K52818472 A549 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132385 BRD-K52818472 HA1E 0.01 uM 24 h 0.0 0.0 0.0 -0.38 -1.27 1.43
132442 BRD-K52818472 HELA 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132489 BRD-K52818472 MCF10A 0.01 uM 24 h 0.33 1.38 0.97 -0.23 -0.76 0.07
132519 BRD-K52818472 MCF??7.00 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132599 BRD-K52818472 THP1 0.25 uM 24 h -0.3 -1.24 0.67 -0.39 -1.3 1.57
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).