CMap Candidate Details
Structure:
| CMap ID: | C02817 |
| Pert ID: | BRD-K03601870 |
| Compound Name: | ixabepilone |
| Targets: | TUBA1A|TUBA1B|TUBA1C|TUBA3C|TUBA3D|TUBA3E|TUBA4A|TUBB|TUBB1|TUBB2A|TUBB2B|TUBB3|TUBB4A|TUBB4B|TUBB6|TUBB8 |
| MoA: | microtubule stabilizing agent |
| SMILES: | C[C@H]1CCC[C@@]2(C)O[C@H]2C[C@H](NC(=O)C[C@H](O)C(C)(C)C(=O)[C@H](C)[C@H]1O)C(\C)=C\c1csc(C)n1 |
| InchiKey: | |
| Compound Aliases: |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 122560 | BRD-K03601870 | A549 | 1.11 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 122591 | BRD-K03601870 | HA1E | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 122615 | BRD-K03601870 | HEK293 | 3.33 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.29 | -0.99 | 0.5 |
| 122667 | BRD-K03601870 | HT29 | 0.37 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 122694 | BRD-K03601870 | MCF10A | 1.11 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 130855 | BRD-K03601870 | A375 | 0.25 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 130947 | BRD-K03601870 | HELA | 0.08 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 131015 | BRD-K03601870 | HUVEC | 0.74 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 131069 | BRD-K03601870 | MCF??7.00 | 0.25 uM | 24 h | -0.26 | -1.07 | 0.28 | 0.0 | 0.0 | 0.0 |
| 131101 | BRD-K03601870 | MDAMB231 | 0.08 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.34 | 1.2 | 1.07 |
| 131135 | BRD-K03601870 | PC3 | 0.74 uM | 24 h | -0.27 | -1.14 | 0.43 | 0.0 | 0.0 | 0.0 |
| 131164 | BRD-K03601870 | YAPC | 2.22 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.29 | -0.97 | 0.46 |