CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C02831
Pert ID:	BRD-K83837640
Compound Name:	JNJ-26481585
Targets:	HDAC1\|HDAC10\|HDAC11\|HDAC2\|HDAC3\|HDAC4\|HDAC5\|HDAC6\|HDAC7\|HDAC8\|HDAC9\|MDM2
MoA:	HDAC inhibitor
SMILES:	Cn1cc(CNCC2CCN(CC2)c2ncc(cn2)C(=O)NO)c2ccccc12
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
34192	BRD-K83837640	ASC	10 uM	24 h	0.0	0.0	0.0	0.27	0.96	0.34
34698	BRD-K83837640	HCC515	10 uM	6 h	0.0	0.0	0.0	-0.28	-0.95	0.42
34974	BRD-K83837640	HEPG2	10 uM	6 h	0.3	1.24	0.52	0.0	0.0	0.0
35477	BRD-K83837640	MCF??7.00	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
35626	BRD-K83837640	NEU	10 uM	24 h	0.21	0.87	0.01	0.4	1.41	2.19
35850	BRD-K83837640	NPC	10 uM	24 h	0.0	0.0	0.0	0.24	0.84	0.13
36364	BRD-K83837640	PHH	10 uM	24 h	0.0	0.0	0.0	-0.23	-0.78	0.09
36662	BRD-K83837640	SKB	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
36880	BRD-K83837640	VCAP	10 uM	24 h	0.0	0.0	0.0	-0.24	-0.82	0.15
95389	BRD-K83837640	U2OS	10 uM	24 h	0.26	1.1	0.24	0.0	0.0	0.0
126058	BRD-K83837640	HT29	0.04 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
126089	BRD-K83837640	HUVEC	0.04 uM	24 h	-0.24	-1.01	0.16	-0.32	-1.08	0.79
126137	BRD-K83837640	JURKAT	0.04 uM	24 h	-0.26	-1.09	0.31	0.25	0.89	0.21
126190	BRD-K83837640	MCF10A	0.04 uM	24 h	0.2	0.83	0.0	-0.29	-0.98	0.49
126269	BRD-K83837640	PC3	0.04 uM	24 h	0.0	0.0	0.0	-0.32	-1.06	0.74
126308	BRD-K83837640	THP1	0.125 uM	24 h	0.0	0.0	0.0	-0.32	-1.08	0.81
134014	BRD-K83837640	A375	0.03 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
134044	BRD-K83837640	A549	0.01 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
134070	BRD-K83837640	HA1E	0.03 uM	24 h	0.26	1.08	0.22	0.28	0.99	0.4
134112	BRD-K83837640	HEK293	0.08 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
134157	BRD-K83837640	HELA	0.03 uM	24 h	0.31	1.29	0.67	-0.36	-1.23	1.25
134265	BRD-K83837640	MDAMB231	0.01 uM	24 h	0.3	1.24	0.51	0.0	0.0	0.0
134319	BRD-K83837640	YAPC	0.01 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary