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CMap Candidate Details

Structure:
CMap ID: C02841
Pert ID: BRD-K11636097
Compound Name: JNJ-7706621
Targets: AURKA|AURKB|CDK1|CDK2
MoA: CDK inhibitor
SMILES: Nc1nc(Nc2ccc(cc2)S(N)(=O)=O)nn1C(=O)c1c(F)cccc1F
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1153 BRD-K11636097 A549 1.11 uM 24 h 0.0 0.0 0.0 -0.27 -0.9 0.29
1170 BRD-K11636097 MCF??7.00 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
1211 BRD-K11636097 PC3 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
1363 BRD-K11636097 U2OS 10 uM 48 h 0.0 0.0 0.0 0.0 0.0 0.0
29786 BRD-K11636097 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
30364 BRD-K11636097 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
30685 BRD-K11636097 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
30967 BRD-K11636097 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
31270 BRD-K11636097 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
31535 BRD-K11636097 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
32136 BRD-K11636097 NEU 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.09 0.83
32355 BRD-K11636097 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
32946 BRD-K11636097 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).