CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C02867
Pert ID:	BRD-K17743697
Compound Name:	KB-R7943
Targets:	SLC8A1\|TRPC3\|TRPC5\|TRPC6
MoA:	sodium/calcium exchange inhibitor
SMILES:	NC(=N)SCCc1ccc(OCc2ccc(cc2)[N+]([O-])=O)cc1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
2844	BRD-K17743697	HA1E	10 uM	24 h	0.29	1.21	0.47	0.36	1.29	1.43
3149	BRD-K17743697	HCC515	10 uM	24 h	0.0	0.0	0.0	0.41	1.45	2.22
3599	BRD-K17743697	PC3	10 uM	6 h	0.0	0.0	0.0	-0.43	-1.44	15.35
3734	BRD-K17743697	VCAP	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
41740	BRD-K17743697	A375	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
42073	BRD-K17743697	A549	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
42319	BRD-K17743697	ASC	10 uM	24 h	0.0	0.0	0.0	0.23	0.83	0.11
42649	BRD-K17743697	HEPG2	10 uM	6 h	0.0	0.0	0.0	0.29	1.01	0.46
42952	BRD-K17743697	HT29	10 uM	6 h	0.0	0.0	0.0	0.31	1.1	0.71
43165	BRD-K17743697	MCF??7.00	10 uM	24 h	-0.21	-0.89	0.03	0.0	0.0	0.0
43510	BRD-K17743697	NPC	10 uM	24 h	0.0	0.0	0.0	0.28	0.98	0.37
43809	BRD-K17743697	PHH	10 uM	24 h	-0.23	-0.95	0.09	0.0	0.0	0.0
44086	BRD-K17743697	SKB	10 uM	24 h	0.0	0.0	0.0	-0.4	-1.36	2.02
100165	BRD-K17743697	U2OS	10 uM	6 h	0.0	0.0	0.0	0.29	1.01	0.46

Summary