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CMap Candidate Details

Structure:
CMap ID: C02871
Pert ID: BRD-K88506063
Compound Name: KD025
Targets: ROCK2
MoA: rho associated kinase inhibitor
SMILES: CC(C)NC(=O)COc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
127727 BRD-K88506063 A375 10 uM 24 h 0.0 0.0 0.0 -0.28 -0.96 0.42
127767 BRD-K88506063 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127844 BRD-K88506063 HEK293 10 uM 24 h -0.24 -1.02 0.18 0.0 0.0 0.0
127918 BRD-K88506063 HUVEC 3.33 uM 24 h 0.28 1.19 0.41 -0.38 -1.28 1.45
127972 BRD-K88506063 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128019 BRD-K88506063 MCF??7.00 10 uM 24 h 0.2 0.82 0.0 -0.21 -0.71 0.03
128040 BRD-K88506063 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135520 BRD-K88506063 HA1E 2.22 uM 24 h 0.0 0.0 0.0 -0.19 -0.62 0.0
135545 BRD-K88506063 HELA 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135596 BRD-K88506063 HT29 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135636 BRD-K88506063 JURKAT 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135735 BRD-K88506063 YAPC 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).