CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C02872
Pert ID:	BRD-K37312348
Compound Name:	kenpaullone
Targets:	CCNB1\|CDK1\|CDK5\|GSK3B
MoA:	CDK inhibitor; glycogen synthase kinase inhibitor
SMILES:	Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
2877	BRD-K37312348	HA1E	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
3361	BRD-K37312348	HCC515	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
3494	BRD-K37312348	PC3	10 uM	24 h	0.0	0.0	0.0	-0.24	-0.82	0.15
3784	BRD-K37312348	VCAP	10 uM	24 h	0.0	0.0	0.0	-0.26	-0.86	0.22
39686	BRD-K37312348	ASC	10 uM	24 h	0.0	0.0	0.0	-0.26	-0.88	0.25
40467	BRD-K37312348	MCF??7.00	10 uM	24 h	0.0	0.0	0.0	-0.34	-1.13	0.99
41441	BRD-K37312348	SKB	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
53395	BRD-K37312348	HEPG2	4 uM	24 h	0.0	0.0	0.0	0.25	0.87	0.17
53509	BRD-K37312348	HUH7	4 uM	24 h	0.0	0.0	0.0	-0.25	-0.83	0.16
53657	BRD-K37312348	PHH	15 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
96138	BRD-K37312348	A549	10 uM	24 h	-0.26	-1.07	0.28	-0.27	-0.92	0.33
97022	BRD-K37312348	A375	10 uM	24 h	0.0	0.0	0.0	0.24	0.85	0.14
99033	BRD-K37312348	NEU	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
99143	BRD-K37312348	NPC	10 uM	24 h	0.22	0.91	0.03	0.0	0.0	0.0
116159	BRD-K37312348	HT29	15 uM	24 h	0.0	0.0	0.0	-0.23	-0.76	0.07

Summary