CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C02877
Pert ID:	BRD-K28936863
Compound Name:	ketotifen
Targets:	HRH1\|PDE4A\|PDE4B\|PDE4C\|PDE4D\|PDE7A\|PDE7B\|PDE8A\|PDE8B\|PGD
MoA:	histamine receptor agonist; leukotriene receptor antagonist; phosphodiesterase inhibitor
SMILES:	CN1CCC(CC1)=C1c2ccsc2C(=O)Cc2ccccc12
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
5602	BRD-K28936863	HCC515	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
24141	BRD-K28936863	VCAP	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
37628	BRD-K28936863	ASC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
37889	BRD-K28936863	HEPG2	10 uM	6 h	-0.23	-0.97	0.11	0.0	0.0	0.0
38455	BRD-K28936863	NPC	10 uM	24 h	0.18	0.75	0.0	0.27	0.96	0.33
38704	BRD-K28936863	PHH	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
38936	BRD-K28936863	SKB	10 uM	24 h	0.22	0.92	0.04	-0.31	-1.04	0.68
91298	BRD-K28936863	HUH7	10 uM	72 h	0.0	0.0	0.0	0.25	0.9	0.22
97575	BRD-K28936863	NKDBA	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
121887	BRD-K28936863	A375	0.125 uM	24 h	0.0	0.0	0.0	-0.33	-1.1	0.86
121933	BRD-K28936863	HA1E	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
122037	BRD-K28936863	HUVEC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
122102	BRD-K28936863	MCF??7.00	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
122184	BRD-K28936863	THP1	0.37 uM	24 h	0.0	0.0	0.0	0.23	0.82	0.1
122213	BRD-K28936863	YAPC	0.125 uM	24 h	-0.27	-1.11	0.37	0.0	0.0	0.0
130196	BRD-K28936863	A549	2.22 uM	24 h	-0.33	-1.36	1.06	0.0	0.0	0.0
130250	BRD-K28936863	HEK293	0.08 uM	24 h	0.27	1.13	0.28	0.0	0.0	0.0
130280	BRD-K28936863	HELA	0.03 uM	24 h	0.0	0.0	0.0	0.25	0.88	0.19
130314	BRD-K28936863	HT29	0.08 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
130339	BRD-K28936863	JURKAT	0.03 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
130389	BRD-K28936863	MCF10A	0.01 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
130444	BRD-K28936863	MDAMB231	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
130475	BRD-K28936863	PC3	0.01 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary