CMap Candidate Details
Structure:
| CMap ID: | C00289 |
| Pert ID: | BRD-K07762753 |
| Compound Name: | aminopurvalanol-a |
| Targets: | CDK1|CDK2|CDK5|CDK6 |
| MoA: | CDK inhibitor; tyrosine kinase inhibitor |
| SMILES: | CC(C)[C@H](CO)Nc1nc(Nc2cc(N)cc(Cl)c2)c2ncn(C(C)C)c2n1 |
| InchiKey: | |
| Compound Aliases: |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 2834 | BRD-K07762753 | HA1E | 10 uM | 24 h | 0.16 | 0.69 | 0.0 | 0.0 | 0.0 | 0.0 |
| 3331 | BRD-K07762753 | HCC515 | 10 uM | 6 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 3593 | BRD-K07762753 | PC3 | 10 uM | 6 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 3940 | BRD-K07762753 | VCAP | 10 uM | 6 h | 0.0 | 0.0 | 0.0 | -0.39 | -1.31 | 1.71 |
| 39089 | BRD-K07762753 | A375 | 10 uM | 6 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 39426 | BRD-K07762753 | A549 | 10 uM | 6 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 39625 | BRD-K07762753 | ASC | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 40226 | BRD-K07762753 | HT29 | 10 uM | 6 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 40589 | BRD-K07762753 | MCF??7.00 | 10 uM | 6 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 40749 | BRD-K07762753 | NEU | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 41377 | BRD-K07762753 | SKB | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.29 | 1.02 | 0.47 |
| 53435 | BRD-K07762753 | HEPG2 | 12.5 uM | 6 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 53498 | BRD-K07762753 | HUH7 | 12.5 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.26 | -0.88 | 0.25 |
| 53642 | BRD-K07762753 | PHH | 50 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 97330 | BRD-K07762753 | HAP1 | 0.66 uM | 24 h | 0.15 | 0.64 | 0.0 | 0.0 | 0.0 | 0.0 |
| 99269 | BRD-K07762753 | U2OS | 50 uM | 6 h | 0.0 | 0.0 | 0.0 | -0.25 | -0.84 | 0.18 |