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CMap Candidate Details

Structure:
CMap ID: C02895
Pert ID: BRD-K64642496
Compound Name: Ko143
Targets: ABCB1|ABCC1
MoA: BCRP inhibitor
SMILES: COc1ccc2c3C[C@@H]4N([C@@H](CC(C)C)c3[nH]c2c1)C(=O)[C@H](CCC(=O)OC(C)(C)C)NC4=O
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
8966 BRD-K64642496 A375 40 uM 24 h -0.17 -0.71 0.0 -0.33 -1.12 0.93
9110 BRD-K64642496 A549 40 uM 24 h -0.21 -0.89 0.04 0.0 0.0 0.0
9472 BRD-K64642496 AGS 40 uM 6 h 0.0 0.0 0.0 -0.21 -0.71 0.04
9778 BRD-K64642496 H1299 40 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9991 BRD-K64642496 HA1E 40 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
10361 BRD-K64642496 HCC515 40 uM 6 h -0.25 -1.03 0.19 -0.18 -0.62 0.0
10560 BRD-K64642496 HCT116 40 uM 6 h -0.22 -0.91 0.05 -0.21 -0.71 0.04
10820 BRD-K64642496 HEPG2 40 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10996 BRD-K64642496 HT29 40 uM 24 h 0.0 0.0 0.0 -0.36 -1.2 1.16
11239 BRD-K64642496 MCF??7.00 40 uM 24 h 0.14 0.6 0.0 -0.37 -1.23 1.29
11537 BRD-K64642496 NCIH2073 40 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11806 BRD-K64642496 NCIH508 40 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12357 BRD-K64642496 NOMO1 40 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12565 BRD-K64642496 PC3 40 uM 24 h 0.0 0.0 0.0 -0.3 -1.02 0.6
12837 BRD-K64642496 SW480 40 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13106 BRD-K64642496 THP1 40 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13323 BRD-K64642496 U937 40 uM 6 h 0.28 1.17 0.38 0.0 0.0 0.0
13653 BRD-K64642496 VCAP 40 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).