CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C00293
Pert ID:	BRD-K17561142
Compound Name:	amiodarone
Targets:	ADRB1\|CACNA1H\|CACNA2D2\|KCNA7\|KCNH2
MoA:	potassium channel blocker
SMILES:	CCCCc1oc2ccccc2c1C(=O)c1cc(I)c(OCCN(CC)CC)c(I)c1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
9377	BRD-K17561142	AGS	10 uM	6 h	0.0	0.0	0.0	0.3	1.07	0.63
9687	BRD-K17561142	H1299	10 uM	6 h	-0.23	-0.96	0.1	0.0	0.0	0.0
10262	BRD-K17561142	HCC515	10 uM	6 h	0.0	0.0	0.0	-0.31	-1.04	0.66
11436	BRD-K17561142	NCIH2073	10 uM	6 h	0.24	0.98	0.09	0.4	1.41	2.19
11727	BRD-K17561142	NCIH508	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
12003	BRD-K17561142	NCIH596	10 uM	6 h	0.0	0.0	0.0	0.24	0.86	0.16
12443	BRD-K17561142	PC3	10 uM	24 h	-0.2	-0.84	0.01	0.0	0.0	0.0
12945	BRD-K17561142	THP1	10 uM	6 h	0.0	0.0	0.0	-0.22	-0.74	0.05
13230	BRD-K17561142	U937	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
13594	BRD-K17561142	VCAP	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
44680	BRD-K17561142	A549	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
44882	BRD-K17561142	ASC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
45184	BRD-K17561142	HEPG2	10 uM	6 h	0.0	0.0	0.0	-0.5	-1.69	15.65
45662	BRD-K17561142	MCF??7.00	10 uM	24 h	-0.25	-1.05	0.23	0.0	0.0	0.0
46317	BRD-K17561142	PHH	10 uM	24 h	0.0	0.0	0.0	0.33	1.16	0.9
46632	BRD-K17561142	SKB	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
90941	BRD-K17561142	HUH7	4 uM	72 h	0.0	0.0	0.0	0.0	0.0	0.0
99008	BRD-K17561142	NEU	10 uM	6 h	0.23	0.95	0.06	-0.51	-1.71	15.65
99131	BRD-K17561142	NPC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
120251	BRD-K17561142	A375	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
120324	BRD-K17561142	HA1E	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
120350	BRD-K17561142	HELA	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
120384	BRD-K17561142	HT29	0.37 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
120487	BRD-K17561142	YAPC	0.37 uM	24 h	-0.2	-0.85	0.01	0.0	0.0	0.0

Summary